CK testing

If you suspect neuromuscular weakness, include a CK as part of your evaluation.

Brain MRI findings

Brain MRI is not an initial or routine component of the evaluation of a weak child.
Abnormal MRI does not exclude a neuromuscular disease.
Most neuromuscular diseases have normal MRI of brain, but some have characteristic abnormalities.

Note of warning:If transaminases (AST and ALT) are elevated, check CK. Since AST/ALT can come from muscle or the liver, while CK comes only from muscle, this test will help localize the child's problem and may prevent unnecessary liver tests.

Download a pdf of the Surveillance and Referral Aid for Primary Care Providers. This Aid includes assessing weakness by age, clinical evaluation for muscle weakness, guidance on the use of CK testing, and the motor delay algorithm. These materials have been endorsed by the American Academy of Pediatrics.

Last Updated on Thursday, 30 August 2012 15:40

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Noting one or more red flags will often expedite a neurology referral.

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CK testing

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