Brain MRI is not an initial or routine component of the evaluation of a weak child.
Abnormal MRI does not exclude a neuromuscular disease.
Most neuromuscular diseases have normal MRI of brain, but some have characteristic abnormalities.
Note of warning:If transaminases (AST and ALT) are elevated, check CK. Since AST/ALT can come from muscle or the liver, while CK comes only from muscle, this test will help localize the child's problem and may prevent unnecessary liver tests.
Early diagnosis can help target interventions, improve outcomes, reduce family distress related to the diagnostic process, and provide the opportunity for accurate genetic counseling. MORE CLINICAL PEARLS
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